RRs (95% CI) of overall, ischemic, and you may hemorrhagic strokes by quintiles regarding combined eating plan scores to possess magnesium, potassium, and you will calcium supplements intakes inside 86,149 feamales in brand new NHS We and you can 94,715 feamales in the new Military Sites and single dating site NHS II step 1
I up-to-date the brand new meta-analyses off potential studies of losing weight magnesium ( 21), potassium ( 22), and you may calcium supplements ( 23) consumption and threat of coronary attack
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
RRs (95% CI) off total, ischemic, and you will hemorrhagic strokes because of the quintiles out-of mutual diet ratings to possess magnesium, potassium, and you may calcium supplements consumption into the 86,149 feamales in brand new NHS I and you may 94,715 women in the brand new NHS II 1
We current the meta-analyses of prospective studies off weight-loss magnesium ( 21), potassium ( 22), and you may calcium supplements ( 23) intakes and you may chance of heart attack
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.
We examined full and you will weight reduction intakes of each and every nutrient and you may risk away from coronary arrest to choose any potential nonlinear connection by using minimal cubic splines; yet not, no tall deviation off linearity are observed. While doing so, we looked the possibility impression modification from the many years, blood pressure, or diabetes into the loved ones between total consumption of all step 3 nutritional elements and danger of total heart attack. No extreme perception modification are noticed by the these issues.
Early in the day meta-analyses provided comes from previous analyses throughout the NHS ( 10); these types of results was indeed changed by the contributes to the modern analysis. Concurrently, new books is actually searched, and latest prospective studies ( 8, 24) was basically utilized in this type of up-to-date meta-analyses. Zero anywhere between-education heterogeneity was observed when it comes down to of your 3 minerals. The brand new shared RR out of total coronary arrest are 0.87 (95% CI: 0.83, 0.92) to have an one hundred-mg/d boost from magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to possess a a thousand-mg/d boost away from potassium consumption, and you can 0.98 (95% CI: 0.94, 1.02) to possess a 3 hundred-mg/d raise of calcium intake.